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Oxidative Medicine and Cellular Longevity
Volume 2018, Article ID 8194721, 11 pages
Research Article

Polyphenolic Compounds, Antioxidant, and Cardioprotective Effects of Pomace Extracts from Fetească Neagră Cultivar

1Department of Horticulture and Landscaping, Faculty of Horticulture, University of Agricultural Sciences and Veterinary Medicine, No. 3-5 Calea Mănăştur Street, Cluj-Napoca 400372, Romania
2Department of Pathophysiology, Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, No. 4-6 Victor Babeş Street, Cluj-Napoca 400012, Romania
3Department of Biochemistry and Biotechnology, Faculty of Oenology, Rovira i Virgili University, C/ Domingo s/n Street, Tarragona 43007, Spain
4Department of Biology, Faculty of Biology and Geology, Babes-Bolyai University, No. 42 Republicii Street, Cluj-Napoca 400015, Romania

Correspondence should be addressed to Alina Elena Pârvu; or.julcfmu@aneleanilauvrap

Received 6 December 2017; Accepted 31 January 2018; Published 22 March 2018

Academic Editor: Ada Popolo

Copyright © 2018 Ştefania Silvia Balea et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Grape pomace is a potential source of natural antioxidant agents. Phenolic compounds and antioxidant and cardioprotective properties of fresh and fermented pomace extracts obtained from Vitis vinifera L. red variety Fetească neagră grown in Romania in 2015 were investigated. Grape pomace extracts total phenolic index, total tannins, total anthocyanins, proanthocyanidins, flavan-3-ol monomers, stilbenes, and DPPH free radical scavenger were measured. The effect of a seven-day pretreatment with grape pomace extracts on the isoprenaline-induced infarct-like lesion in rats was assessed by ECG monitoring, serum levels of creatine kinase, aspartate transaminase, and alanine transaminase. Total serum oxidative status, total antioxidant response, oxidative stress index, malondialdehyde, total thiols, and nitric oxide have been also assessed. Higher phenolic content and antioxidant activity were found in fermented pomace extracts when compared to fresh pomace extracts. Pretreatment with grape pomace extracts significantly improved cardiac and oxidative stress parameters. In conclusion, Fetească neagră pomace extracts had a good in vitro antioxidant activity due to an important phenolic content. In vivo, the extracts had cardioprotective effects against isoprenaline-induced infarct-like lesion by reducing oxidative stress, fresh pomace extracts having a better effect.