Review Article
How Supraphysiological Oxygen Levels in Standard Cell Culture Affect Oxygen-Consuming Reactions
Table 5
Hypoxia effects on the expression of some O2-consuming enzymes.
| | Enzyme | Effect | Reference |
| | Nox1 | Transcriptional stimulation by HIF-1 | Goyal et al. 2004 | | Nox4 | Transcriptional stimulation | [93] | | nNOS | Transcriptional stimulation | [94] | | eNOS | Transcriptional stimulation | [95] | | Stabilization of mRNA | [96] | | iNOS | Transcriptional stimulation by HIF-1 | [97–99] | | XO | Transcriptional stimulation | [54] | | MAO | Transcriptional stimulation | [100] | | HO | Transcriptional stimulation | [101] | | LOX | Transcriptional stimulation | [102] | | COX | Transcriptional stimulation | Demasi et al. 2004; | | AQP1 | Transcriptional stimulation | [103] | | AQP3 | Transcriptional stimulation | Hoogewijs et al. 2016 | | AQP5 | Transcriptional repression | [34] | | AQP9 | Unclear mechanism | Castro-Parodi et al. 2013 |
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Nox: NADPH oxidase; NOS: nitric oxide synthase; XO: xanthine oxidase; MAO: monoamine oxidase; HO: heme oxygenase; LOX: lipoxygenase; COX: cyclooxygenase; AQP: aquaporin.
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