Gefitinib Inhibits Bleomycin-Induced Pulmonary Fibrosis via Alleviating the Oxidative Damage in Mice

Figure 9

Gefitinib treatment decreased phosphorylation of NF-κB, c-Jun, and c-Fos in the lung tissues affected by pulmonary fibrosis. Lung tissues from gefitinib- (Ge-) treated and PBS-treated pulmonary fibrosis mice were collected two weeks after bleomycin (BLM) administration. (a) The total phosphorylation of NF-κB, c-Jun, and c-Fos in the lung tissues were detected by Western blot. (b) The relative band densities were calculated. Gefitinib treatment significantly inhibited the phosphorylation of NF-κB, c-Jun, and c-Fos induced by BLM administration in mice. All data were expressed as the mean ± SD, . versus BLM group.

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