Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway

Figure 4

Photomicrographs for hepatic sections stained with hematoxylin and eosin. (a) Section of the liver from the saline group showing normal polyhedral hepatic cells which are arranged in cords that are radically arranged around the central veins. (b) Liver section from the DOX- (6 mg/kg/week) treated group showing marked necrosis of hepatocytes (N), hepatic cell which indicated obscure and fiberized boundary with inflammatory cell infiltration (black arrow), dilatation, and congestion of central veins and portal blood vessels (CO). (c) Section of the liver from the DOX control group showing nuclear pyknosis (white arrow), diffuse vacuolar degeneration (black arrow), and severe congestion of portal blood vessels (co) along with lymphocytic infiltration (black arrow), proliferation of bile duct, and fibrosis. (d) Liver section from mice treated with DOX (6 mg/kg/week) + BAs (125 mg/kg/day) demonstrating hepatic cells showing focal areas of vacuolar degeneration (black arrow). (e) Liver section from mice treated with DOX (6 mg/kg/week) + BAs (250 mg/kg/day) showing normal hepatocytes, mild to moderate vacuolar degeneration (arrow head), and mild hyperemia in the sinusoids (black arrow). (f) Sections from mice treated with DOX (6 mg/kg/week) + BAs (500 mg/kg/day) showing fairly normal tissue architecture and cellular details with mild vacuolar degeneration (black arrow).

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