Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats

Figure 7

Light micrographs of testicular tissues of rats treated with olive leaf extract (OLE) and cisplatin (CDDP). (a) Photomicrograph of the testicular tissue of the control group showing healthy seminiferous tubules at all stages of spermatogenic cells (primary spermatocyte “black arrow” and spermatids “blue arrow”) and the interstitial cells with Leydig cells (black star) filling the space between the seminiferous tubules. (b) Photomicrograph of the testicular tissue of rats treated with CDDP showing degenerative alterations (red star) in spermatogenic cells and the detachment of the spermatogenic epithelium. (c) Photomicrograph of the testicular tissue of rats treated with OLE alone showing a healthy histological structure. (d) Photomicrograph of the testicular tissue of rats treated with OLE and CDDP showing a recovery of spermatogenic epithelium in most seminiferous tubules. Sections were stained with hematoxylin and eosin (400x).

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