Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via AMPK-Dependent TXNIP/NLRP3 Pathway

Figure 3

Salidroside (SAL) alleviates oxidative stress and inflammatory reaction in HFD mice. After treatment with SAL (100 mg·kg⁻¹·d⁻¹) for 8 weeks, serum and liver tissues were obtained from RD and HFD mice. The SOD activity (a), MDA content (b) in serum/liver tissues, and IL-1β concentration (c) in serum were measured. Liver sections were prepared for CD68 staining (d). Total RNA was extracted from liver tissue, and the gene expression levels of Fas, Mcp1, Tnfα, Nlrp3, caspase1, Il1β, and Il18 were analyzed (e). Scale bar = 200 μm. , versus RD mice treated with vehicle; versus HFD mice treated with vehicle. Values are means ± s.e.m. ((a)–(c): ; (d) and (e): ).

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