Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 6

Research Article

6-O-Galloylpaeoniflorin Attenuates Cerebral Ischemia Reperfusion-Induced Neuroinflammation and Oxidative Stress via PI3K/Akt/Nrf2 Activation

Figure 6

GPF decreases oxidative stress through the PI3K/Akt pathway in a rat CIRI model. The SOD, GSH, and GSH-Px activities as well as the MDA level were analyzed in the indicated groups in the brain tissue of MCAO rats (a). (b) Nrf2 nuclear translocation was determined by a Western blot assay in the isolated nuclear fraction of the brain tissue of MCAO rats in each group (upper left panels of (b)). Densitometric analysis of the Nrf2 Western blot images is presented in the upper right panels of (b). The HO-1 expression and the corresponding densitometry of the indicated groups were analyzed as well (lower panels of (b)). Each group contains at least six rats. versus 0 mg/kg GPF in the CIRI models; versus 0 mg/kg GPF in the CIRI models; versus 10 mg/kg in the CIRI models; versus 10 mg/kg in the CIRI models.

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