6-O-Galloylpaeoniflorin Attenuates Cerebral Ischemia Reperfusion-Induced Neuroinflammation and Oxidative Stress via PI3K/Akt/Nrf2 Activation

Figure 8

GPF relieved cell apoptosis in a rat CIRI model in vivo. Rat brain slices of the indicated groups were stained with a TUNEL assay kit (a). The TUNEL-positive cells (yellow-brown, elliptical, or round) of each corresponding group were counted (b). The activity of caspase-3 was detected in the rat brain samples of the indicated groups (c). Each group contains at least six rats. versus 0 mg/kg GPF in the CIRI models; versus 0 mg/kg GPF in the CIRI models; versus 10 mg/kg GPF in the CIRI models.

(a)

(b)

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