Citrus aurantium Naringenin Prevents Osteosarcoma Progression and Recurrence in the Patients Who Underwent Osteosarcoma Surgery by Improving Antioxidant Capability

Figure 5

H&E staining was also performed on osteosarcoma samples at different stages. (a) The osteosarcoma consists of an atypical round to cell proliferation with osteoid deposition at G1 stage (H&E stain ×200). (b) Osteosarcoma cells shape variable with chromatic nuclei and mitosis fields at G2 stages. (c) Spindle cell neoplasm has high cellularity, abnormal mitotic characters, and atypical nuclear at the G3 stage. (d) The osteosarcoma forms a highly cancerous and high-mortality bone tumor at the G4 stage.

(a)

(b)

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