Ex Vivo Cardiotoxicity of Antineoplastic Casiopeinas Is Mediated through Energetic Dysfunction and Triggered Mitochondrial-Dependent Apoptosis

Figure 2

Cas affect contractility on isolated rat hearts. Cas were perfused at 5 μM for 60 minutes (a) or in a dose-dependent manner (b). The blue squares indicate III-Ea, green triangles indicate II-gly, and red circles indicate III-ia. Black rhombuses indicate control and yellow rhombuses indicate Doxo treatment. Values are mean ± SEM. ( experiments at least for each treatment).

(a)

(b)