Ex Vivo Cardiotoxicity of Antineoplastic Casiopeinas Is Mediated through Energetic Dysfunction and Triggered Mitochondrial-Dependent Apoptosis

Table 1

Dose- and time-dependent parameters of hearts treated with Cas.

	Cas III-ia; ()	Cas II-gly; ()	Cas III-Ea; ()	Doxo; ()
IC50 (μM)	10 ± 0.7^a,b,c	5.5 ± 0.5^b,d	1.3 ± 0.2^a,b,d	5 ± 0.3^c,d
t0.5 (min)	49 ± 0.8^a,b,c	29 ± 1.0^d	21 ± 5.0^d	18.6 ± 4.0^d

The time for half-inhibition (t_0.5) at 5 μM and the half-maximal inhibitory concentration (IC₅₀) at 30 min of Cas-treated hearts. Values are mean ± SEM. versus ^aDoxo, ^bII-gly, ^cIII-Ea, and ^dIII-ia ( experiments at least for each treatment).