Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF-κB-Mediated Inflammation

Figure 4

Andro treatment suppresses NF-κB activation in the diabetic myocardium. (a and b) Western blot analysis of p65NF-κB, p-IκBα, and COX-2 expression in the myocardial tissues. (c and d) Gel shift assay showed that NF-κB activation was inhibited by Andro treatment. (e) Western blot analysis of p65NF-κB and p-IκBα expression in H9c2 cells in response to different glucose concentrations. (f) Effect of Andro treatment on the expression of p65NF-κB and p-IκBα. HG, 25 mM glucose. compared to control; compared to DM.

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