Oxidative Medicine and Cellular Longevity / 2018 / Article / Tab 1

Corrigendum

Corrigendum to “Haptoglobin Genotype and Outcome after Subarachnoid Haemorrhage: New Insights from a Meta-Analysis”

Table 1

Reported differences between Hp types, relevant to SAH.

FunctionNo difference between Hp typesDifference between Hp types

Hp expressionSerum Hp1-1 is higher than Hp2-2, with Hp2-1 intermediate, in many populations tested, including European (Belgian [37–39], Iceland [40]), East Asian (Japanese [41], Koreans [42]), and African (Black Zimbabweans [43], Gabonese [44], Papuans [45]).
Haemoglobin binding: capacity per Hp monomer(1) Ultrafiltration assay of uncomplexed Hb [46]
(2) Mass spectrometry [24]
Haemoglobin binding: affinity(1) Surface plasmon resonance [47]
(2) Surface plasmon resonance [24]
(3) Spectrophotometric signal of Hp-Hp interaction [48]
Inhibition of Hb-mediated oxidation(1) Reduction in low-density lipoprotein oxidation [24]
(2) Reduction in Hb intrinsic redox potential [48]
(3) Reduction in Hb autooxidation [17]
(1) Hp1-1 is better than Hp2-2 at inhibiting protein and lipid oxidation [49].
(2) Hp1-1 is better than Hp2-2 at inhibiting oxidation of linolenic acid and low-density lipoprotein [46].
(3) Hp1-1 is better than Hp2-2 at inhibiting lipid peroxidation [47].
Interaction with CD163: affinity(1) Hp2-2 is better than Hp1-1, by surface plasmon resonance and binding of radioiodinated Hp-Hb complexes in vitro [1].
(2) Hp2-2 is better than Hp1-1, by binding of radioiodinated Hp-Hb complexes in vitro [50].
Interaction with CD163: uptake of Hp-Hb complexesPlasma half-life of Hp-Hb complexes after injection in guinea pigs [24](1) Hp2-2 is better than Hp1-1, by measurement of free Hb in humans [51].
(2) Hp1-1 is better than Hp2-2, by uptake of radioiodinated Hp-Hb complexes in human cells in vitro [50].
Effects on inflammationBinding of Hp1-1-Hb complexes to CD163 results in secretion of the anti-inflammatory cytokine IL-10 [19, 20].