Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3<i>β</i> Activity

<div>Molecular docking and hydrogen bonding interactions. (a) Molecular redocking of indirubin-3<svg height="11.4859pt" id="M67" style="vertical-align:-0.04979992pt" version="1.1" viewbox="-0.0498162 -11.4361 3.89517 11.4859" width="3.89517pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M310 541L304 571C290 586 211 619 185 610L80 76L131 52L310 541Z" id="g50-31"></path></g></svg>-monoxime with GSK3<i>β</i>. The crystal and redocked poses are shown in green and blue, respectively. (b) Molecular docking and hydrogen bonding interactions of fisetin with GSK3<i>α</i>. Hydrogen bonding interaction is shown as dotted green lines. (c) Molecular docking and hydrogen bond interactions of fisetin with GSK3<i>β</i>. Hydrogen bond interactions are shown as dotted red lines.</div>

Oxidative Medicine and Cellular Longevity

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Figure 9

Figure 9: Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3<i>β</i> Activity 

Figure 9 | Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3β Activity 