Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3β Activity

Table 1

Effect of fisetin on hemodynamic parameters.

Group	LVSP	LVDP	RPP	+dp/dt	−dp/dt
	(mmHg)	(mmHg)	(mmHg BPM × 10^3)	(mmHg/s)	(mmHg/s)
Sham ()	120.0 ± 2.2	13 ± 1.3	36.3 ± 0.26	3001.0 ± 23.3	3207.0 ± 13.4
Fisetin + sham ()	117.0 ± 5.2	12 ± 2.2	35.7 ± 0.23	2994.0 ± 21.2	3200.0 ± 14.2
I/R ()	27.0 ± 2.9	16 ± 3.1	4.7 ± 0.34	1729.7 ± 22.6	1126.7 ± 12.3
Fisetin + I/R ()	110.8 ± 2.5^#	13 ± 2.6^#	29.3 ± 0.25^#	2842.0 ± 26.9^#	2974.3 ± 15.5^#

LVSP: left ventricular systolic pressure; LVDP: left ventricular diastolic pressure; RPP: rate pressure product; ±dp/dt: ventricular contraction assessment. versus sham/fisetin + sham; versus I/R.