Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways

Figure 6

Effect of guarana hydroalcoholic extract (GHE) treatment on intracellular ROS accumulation in C. elegans. (a) Wild-type and (b) CL2006 animals were treated with either 10 or 50 mg/mL GHE from L1 until L4. For wild-type animals, ROS production was evaluated on both standard and stress conditions induced by 5 mM H₂O₂ for 1 h. ROS levels were measured using the dye H₂DCFDA. Results are expressed as H₂DCFDA fluorescence relative to untreated controls. , , and , two-tailed Student -test.

(a)

(b)