Research Article

The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats

Figure 5

Effect of estradiol and sinapic acid on the serum concentrations of oxidative damage markers: thiobarbituric acid-reactive substances (TBARS), advanced oxidation protein products (AOPP), and protein carbonyl groups (PCG) in ovariectomized rats. Sinapic acid at doses of 5 mg/kg (SA5) and 25 mg/kg (SA25) or estradiol ((ESTR) 0.2 mg/kg) was administered orally to ovariectomized rats, once daily for 28 days. SHAM: sham-operated control rats; OVX: ovariectomized control rats. Results are presented as the mean ± SEM. The concentration of AOPP is presented in chloramine T equivalents. One-way ANOVA followed by Fisher’s LSD test was used for evaluation of statistical significance of the results. , : significantly different from the OVX control rats. No statistically significant differences in results for TBARS and PCG were demonstrated in ANOVA.