Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs

Figure 1

Daily calorie intake, body weight variation, and changes in blood glucose levels as a function of time in different treatment groups. (a) HC-fed rats (red) consumed higher calories on a daily basis compared to control rats on normal chow (black). Depicted data are mean ± SEM for eight control and 32 HC-fed rats. Daily calorie intake was significantly higher on most treatment days, as estimated by two-way ANOVA. (b) No differences in weight gain were detected among the different treatment groups over twelve weeks of treatment. (c) No significant differences in random blood glucose levels were detected among the different treatment groups over twelve weeks of treatment. (d) At the end of the treatment period, different groups responded similarly to an oral glucose load. Data depicted in (b–d) represent mean ± SEM of values obtained from eight rats in each treatment groups.

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