Research Article

Exogenous Hydrogen Sulfide Supplement Attenuates Isoproterenol-Induced Myocardial Hypertrophy in a Sirtuin 3-Dependent Manner

Figure 2

Effect of NaHS on blood pressure in WT mice and SIRT3 KO mice after ISO administration. Male 129S1/SvImJ (WT) and SIRT3 knockout (KO) mice at 10 weeks of age were administrated with NaHS (50 μmol/kg/d) or normal saline (NS) once daily. After 2 weeks, the mice were given isoproterenol (ISO, 60 mg/kg) by intraperitoneal injection followed by NaHS or NS administration once daily for another 2 weeks. (a–c) Invasive arterial blood pressures, including systolic blood pressure (SBP), diastolic blood pressures (DBP), and mean arterial pressure (MAP), were measured from left carotid artery. Plots represent the mean ± SEM; .
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