Research Article

Prophylactic Zinc and Therapeutic Selenium Administration Increases the Antioxidant Enzyme Activity in the Rat Temporoparietal Cortex and Improves Memory after a Transient Hypoxia-Ischemia

Figure 3

The combined treatment with zinc and selenium increased the enzymatic activity and transcription of glutathione peroxidase in the late phase of hypoxia-ischemia in the rat. (a) Enzymatic activity of GPx and (b) mRNA levels of GPx4. CCAO: common carotid artery occlusion for 10 min; Zn + CCAO: chronic zinc administration before CCAO; Zn + CCAO + Se: chronic zinc administration before CCAO followed by selenium administration. The values were normalized against the control group. Each value represents of 5 independent experiments made in triplicate. , one-way ANOVA with post hoc Dunnett’s test when compared to the control untreated group; , Student’s -test when compared with the respective CCAO group.
(a)
(b)