Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 2

Research Article

Enhanced Oxidative Damage and Nrf2 Downregulation Contribute to the Aggravation of Periodontitis by Diabetes Mellitus

Figure 2

Diabetes aggravated alveolar bone loss and apoptosis of periodontal cells in periodontitis. (a) Macroscopic aspects of the mandibles observed in the C, D, P, and DP groups. The black lines showed the distance from the amelocemental junction (ACJ) to the alveolar crest (AC) (bar = 1 mm). (b) Quantitative analysis of the ACJ-AC distance and bone loss area. (c) Apoptosis of periodontal cells was determined by the TUNEL assay and expressed as the apoptotic rate. TUNEL staining (with DAPI costaining) with nuclei being stained with blue is shown. TUNEL-positive nuclei are green/cyan (bar = 25.5 um). (d) Demonstrated apoptotic cell number per microscopic field. Data shown are mean ± SD (/each group). NS: nonsignificantly different from the C group. versus the C group. versus the P group. (C: no treatment; P: experimentally induced periodontitis; D: experimentally induced diabetes mellitus; DP: experimentally induced diabetes and periodontitis.)

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19. Sign up here as a reviewer to help fast-track new submissions.