Oxidative Medicine and Cellular Longevity / 2018 / Article / Fig 4

Research Article

Enhanced Oxidative Damage and Nrf2 Downregulation Contribute to the Aggravation of Periodontitis by Diabetes Mellitus

Figure 4

Diabetes exacerbated the decrease in the protein level and gene expression of Nrf2 in periodontitis. (a) Representative figures from anti-Nrf2 immunohistochemistry staining of alveolar sections from the C, D, P, and DP groups (NC: negative control). Quantitative analyses of (b) Nrf2-positive nuclei and (c) the expression level in the gingiva. (d) Representative immunoreactive bands for Nrf2 in periodontal tissues in the indicated groups and the total protein level of Nrf2 relative to GAPDH. (e) Real-time PCR analysis of Nrf2 in periodontal soft tissues of the indicated groups. Results are expressed as mean ± SD (). NS: nonsignificantly different from the C group; significantly different from the C group; and versus the P group. (C: no treatment; P: experimentally induced periodontitis; D: experimentally induced diabetes mellitus; DP: experimentally induced diabetes and periodontitis.)

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