Grape Seed Proanthocyanidin Ameliorates Cardiac Toxicity Induced by Boldenone Undecylenate through Inhibition of NADPH Oxidase and Reduction in the Expression of NOX2 and NOX4

<div class="floats-full-page floats-full-page-figure"><h2>Figure 5</h2><div class="floats-full-page-caption"><div>Photomicrographs of heart sections stained with PCNA-ir in the different groups. (a, b) Faint positive reaction (arrows) for PCNA-ir in control (G1) and GSPE (G2) groups. (c)  A strong positive reaction (arrows) for PCNA-ir in heart sections of rats treated with Boldenone (G3). (d) PCNA reactivity was decreased significantly (moderate positive reaction for PCNA-ir in treated rats with Boldenone and GSPE) (G4).</div></div><div class="floats-full-page-content"><table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static-01.hindawi.com/articles/omcl/volume-2018/9434385/figures/9434385.fig.005a.svgz" name="9434385.fig.005a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b></td></tr><tr class="fig-image" id="b"><td><object data="https://static-01.hindawi.com/articles/omcl/volume-2018/9434385/figures/9434385.fig.005b.svgz" name="9434385.fig.005b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b></td></tr><tr class="fig-image" id="c"><td><object data="https://static-01.hindawi.com/articles/omcl/volume-2018/9434385/figures/9434385.fig.005c.svgz" name="9434385.fig.005c" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(c) </b></td></tr><tr class="fig-image" id="d"><td><object data="https://static-01.hindawi.com/articles/omcl/volume-2018/9434385/figures/9434385.fig.005d.svgz" name="9434385.fig.005d" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(d) </b></td></tr></table></div></div>

Figure 5 | Grape Seed Proanthocyanidin Ameliorates Cardiac Toxicity Induced by Boldenone Undecylenate through Inhibition of NADPH Oxidase and Reduction in the Expression of NOX2 and NOX4

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Figure 5: Grape Seed Proanthocyanidin Ameliorates Cardiac Toxicity Induced by Boldenone Undecylenate through Inhibition of NADPH Oxidase and Reduction in the Expression of NOX2 and NOX4

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Figure 5

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<p><em>Oxidative Medicine and Cellular Longevity </em>publishes research involving cellular and molecular mechanisms of oxidative stress in the nervous system and related organ systems in relation to aging, immune function, vascular biology, metabolism etc.</p>


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<p>Chief Editor, Dr Vasquez-Vivar has experience in free radical and redox biology research including the discovery of the role of tetrahydrobiopterin in the regulation of superoxide generation by endothelial and neuronal nitric oxide synthase.</p>


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