Inhibition of HDAC6 Activity Alleviates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation
Effects of TubA on apoptosis rate, infract size, serum biomarks, and LV hemodynamic parameters in diabetic rats. Diabetic rats were subjected to 45 min of ischemia followed by 3 h of reperfusion. Tubastatin A (10 mg/kg) was administrated daily by i.p. injection for 1 week in diabetic rats. D: STZ-induced diabetic rats; S: sham operation; IR: ischemia/reperfusion; TubA: tubastatin A. (a) Representative TUNEL staining image and apoptosis rate of each group. (b) Infarct area versus area at risk (IA/AAR × 100%). (c) Serum CK-MB levels. (d) Serum LDH levels. LV hemodynamic parameters including LVSP (e), +dp/dt max (f), and −dp/dt max (g) were measured in each group. All values are presented as the mean ± SEM, /group. versus DIR group, versus DS group.
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