Inhibition of HDAC6 Activity Alleviates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation

Figure 3

Effects of TubA on apoptosis rate, infract size, serum biomarks, and LV hemodynamic parameters in diabetic rats. Diabetic rats were subjected to 45 min of ischemia followed by 3 h of reperfusion. Tubastatin A (10 mg/kg) was administrated daily by i.p. injection for 1 week in diabetic rats. D: STZ-induced diabetic rats; S: sham operation; IR: ischemia/reperfusion; TubA: tubastatin A. (a) Representative TUNEL staining image and apoptosis rate of each group. (b) Infarct area versus area at risk (IA/AAR × 100%). (c) Serum CK-MB levels. (d) Serum LDH levels. LV hemodynamic parameters including LVSP (e), +dp/dt max (f), and −dp/dt max (g) were measured in each group. All values are presented as the mean ± SEM, /group. versus DIR group, versus DS group.

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