Inhibition of HDAC6 Activity Alleviates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation
Effect of TubA on oxidative stress in MI/R diabetic rats. After diabetic rats were subjected to 45 min of ischemia followed by 3 h of reperfusion, H2O2, MDA, lipid hydroperoxide level, and O2− production were measured to assess the oxidative stress. D: STZ-induced diabetic rats; S: sham operation; IR: ischemia/reperfusion; TubA: tubastatin A. (a) Cardiac tissue H2O2 concentration. (b) Cardiac tissue superoxide anion production. (c) Cardiac tissue MDA content. (d) Cardiac tissue lipid hydroperoxide. All values are presented as the mean ± SEM, /group. versus DIR group, versus DS group.
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