Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications

Figure 10

Vitamin D supplementation putatively reduces CVR by lowering PTH serum levels. Since vitamin D exposure failed to lower PTH-dependent ROS production, we can assume that the correction of CVR depends on PTH serum level normalization. This effect derives from both PTH gene downregulation by vitamin D/vitamin D intracellular receptor complex and increased blood Ca²⁺ concentrations.