Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways

Figure 6

Effects of H₂S on the inflammation, proliferation, and apoptosis in the diaphragm of septic rats. (a–f) The expressions of MCP-1, TNF-α, IL-1β, IL-6, IL-10, and IL-18 were detected by qRT-PCR. Data are presented as mean ± SEM of three independent experiments. (g) Representative photographs of HE, Ki67, and cleaved caspase-3 staining in the diaphragm of rats; original magnification, ×400. (h, i) The proliferation index and apoptosis index were calculated. Values were presented as mean ± SEM (). and compared with the control group; and compared with the LPS group.

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