Nocturnal Hypoxia Improves Glucose Disposal, Decreases Mitochondrial Efficiency, and Increases Reactive Oxygen Species in the Muscle and Liver of C57BL/6J Mice Independent of Weight Change

Table 1

Weight change, food intake, plasma lactate, and plasma free fatty acids (FFA) over two-week exposure to room air (Air), nocturnal 10% hypoxia (N10%), and continuous 10% hypoxia (C10%) in lean and obese mice. Data shown as mean ± s.e.m. and statistical differences between day 0 and day 14 were determined by two-tailed paired t-test. Two-way ANOVA for lactate showed a significant effect of hypoxia (F(2,41) = 4.3; ) and obesity (F(1,41) = 34; ) and a significant interaction between hypoxia and obesity (F(2,41) = 3.3; ).

		Air	N10%	C10%
Weight day 0 (g)	Lean	26.0 ± 0.6	24.7 ± 0.6	24.6 ± 0.5
	Obese	46.7 ± 1.6	46.9 ± 1.2	43.8 ± 1.5
Weight day 14 (g)	Lean	26.2 ± 0.5	25.8 ± 0.6	24.0 ± 0.4
	Obese	48.6 ± 1.7	47.1 ± 1.2	38.5 ± 1.8
Weight change (g)	Lean	0.3 ± 0.3	1.1 ± 0.2	−0.6 ± 0.2
	Obese	1.9 ± 0.7	0.1 ± 0.1	−5.3 ± 0.6
Weight change (%)	Lean	1.1 ± 1.0	4.3 ± 0.8	−2.4 ± 0.8
	Obese	4.2 ± 1.5	0.3 ± 0.4	−12.4 ± 1.6
Food intake (kcal/day)	Lean	10.5 ± 0.5	9.1 ± 0.3	8.3 ± 0.1
	Obese	13.4 ± 0.5	11.7 ± 0.2	8.2 ± 0.2
Lactate (nM)	Lean	4.1 ± 0.4	5.6 ± 0.6	6.0 ± 0.5
	Obese	3.6 ± 0.4	3.4 ± 0.2	3.8 ± 0.01
FFA (mM)	Lean	0.30 ± 0.05	0.22 ± 0.03	0.23 ± 0.01
	Obese	0.33 ± 0.07	0.24 ± 0.02	0.24 ± 0.02