Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response

<div>Matrine-induced oxidative stress in HL-7702 cells. Cells were incubated with matrine (0-4 mg/mL) for 48 h. (a) ROS detection with DCFH-DA dye in different groups by flow cytometry. (b) Lipid peroxidation MDA content and antioxidant SOD or GSH level in cells were measured. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response 

Figure 5 | Matrine Exerts Hepatotoxic Effects via the ROS-Dependent Mitochondrial Apoptosis Pathway and Inhibition of Nrf2-Mediated Antioxidant Response 