Suppression of Mouse AApoAII Amyloidosis Progression by Daily Supplementation with Oxidative Stress Inhibitors

Figure 6

High-dose supplementation exhibits a consistent preventive effect against amyloidosis with the initial dose. (a) The amyloid index was significantly lower in the Tem and Apo groups compared with the A-NT group after 12-week-supplementation. Comparison of IHC-positive areas showed decreased amyloid deposition in the Tem and Apo groups in the (b) skin and (c) liver. (d) Representative polarized LM and IHC images of AApoAII deposits (red arrows) in the liver in induced mice. Results are shown as box and whisker plots, where a box extends from the 25th to the 75th percentile with the median shown as a line in the middle and whiskers indicate the smallest and largest values. Each dot represents an individual mouse (a). Each scale bar indicates 50 μm (d). Each column and bar represents the . (b, c) (Con) and 5 (A-NT, Tem, and Apo). , the Kruskal-Wallis test with the Steel-Dwass test (a). , the Tukey-Kramer method for multiple comparison (b, c).

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