Long Noncoding RNAs in the Regulation of Oxidative Stress

Table 1

lncRNA involving in oxidative stress.

lncRNA	Functions	Relevant pathways	References
MALAT1	(1) Downregulating Keap1	Nrf2/Keap1/ARE	[29]
	(2) Preemptively binding with Nrf2 to inhibit the expression of Nrf2-target genes	Nrf2/Keap1/ARE	[30]
	(3) Binding with SP1	p38MAPK	[32]
	(4) Targeting miR-145 to enhance the expression of VEGF-A and ANGPT2	—	[33]
H19	(1) Antagonizing the premature senescence of CPC	—	[35]
	(2) Attenuating oxidative stress and inflammation in the diabetic mouse model	—	[36]
	(3) As a competing endogenous molecule to affect the invasion and migration ability of cholangiocarcinoma cells	—	[37]
SCAL1	Driven by Nrf2, and protecting airway epithelial cells from oxidative stress	Nrf2/Keap1/ARE	[38]
NEAT1	(1) Reversing the superoxide in LPS-treated rat mesangial cells	—	[41]
	(2) Figured as a neuroprotector in nerve injury caused by oxidative stress	—	[42]
gadd7	Induced by ROS, and low expression of gadd7 could significantly lower the ROS	—	[45]
MACC1-AS1	Promoting the proliferation of gastric cancer cells, inhibiting apoptosis, and regulating metabolism	AMPK/Lin28	[47]
ODRUL	Contributing to the toxicity in erythroid cells induced by AgNPs	Nrf2/Keap1/ARE; PI4K-AKT/JNK	[48]
LINC01619	A “sponge” of miR-27a	—	[49]
LINC00963	Attenuating renal fibrosis and oxidative stress in chronic renal	—	[51]
FOXD3-AS1	A “sponge” of microRNA-150	—	[53]
BDNF-AS	Involving in decreasing cell viability and increasing cell apoptosis induced via oxidative stress	—	[55]