Scutellarin Exerts Hypoglycemic and Renal Protective Effects in db/db Mice via the Nrf2/HO-1 Signaling Pathway

Table 1

The effect of SCU and Met on organ indexes, food intake, and water intake in db/db mice.

		db/m^+	db/db	db/db + Met (mg/kg)	db/db + SCU (mg/kg)
				120	25	50	100
Organ index %	Liver	4.5 ± 0.8	5.5 ± 0.2	5.1 ± 0.3	4.5 ± 0.6	5.4 ± 0.3	5.3 ± 0.3
	Heart	0.58 ± 0.04	0.28 ± 0.009^###	0.31 ± 0.01	0.31 ± 0.02	0.32 ± 0.02	0.34 ± 0.02
	Spleen	0.31 ± 0.008	0.15 ± 0.02^###	0.15 ± 0.03	0.14 ± 0.01	0.14 ± 0.007	0.15 ± 0.01
	Kidney	1.42 ± 0.04	0.75 ± 0.02^###	0.84 ± 0.06	0.76 ± 0.01	0.74 ± 0.02	0.78 ± 0.04
Food intake (g/100 g)		8.7 ± 1.3	22.1 ± 0.8^###	13.4 ± 0.6	10.9 ± 1.1	12.8 ± 1.4	14.0 ± 1.8
Water intake (g/100 g)		27.9 ± 1.6	65.4 ± 4.1^###	37.6 ± 3.3	32.7 ± 2.7	36.0 ± 2.5	34.0 ± 5.0

versus db/m⁺ mice, , , and versus vehicle-treated db/db mice.