Scutellarin Exerts Hypoglycemic and Renal Protective Effects in db/db Mice via the Nrf2/HO-1 Signaling Pathway

Table 3

The regulatory effects of SCU and Met on the levels of oxidative cytokines.

		db/m^+	db/db	db/db + Met (mg/kg)	db/db + SCU (mg/kg)
				120	25	50	100
Serum	CAT (U/mL)	71.8 ± 0.5	52.5 ± 1.5^##	54.2 ± 1.4	56.2 ± 2.2	54.4 ± 0.7	59.3 ± 1.3
	GSH-Px (U/mL)	293.7 ± 10.2	249.3 ± 5.1^#	265.5 ± 6.8	267.5 ± 10.3	267.9 ± 3.9	310.5 ± 13.8
	SOD (U/mL)	250.8 ± 12	137.5 ± 21.5^###	206.8 ± 6.9	196.2 ± 16.4	200.4 ± 12.6	206.9 ± 15.6
	MDA (nmol/mL)	21.2 ± 0.4	20.1 ± 0.6	17.2 ± 0.6	16.1 ± 0.5	15.3 ± 0.5	16.2 ± 0.5
Kidney	CAT (U/mgprot)	22.4 ± 0.8	18.9 ± 0.9^#	24.8 ± 0.9	23.5 ± 1.5	21 ± 0.9	22 ± 0.5
	GSH-Px (U/mgprot)	110.5 ± 4.2	98.5 ± 4.3^#	136.5 ± 8.8	133.4 ± 9.1	114.2 ± 9.8	114.9 ± 2.1
	SOD (U/mgprot)	180.4 ± 6.6	135.7 ± 9.6^#	168.1 ± 11.3	203 ± 6.8	206 ± 11.6	206 ± 12
	ROS (U/mgprot)	136.6 ± 3.7	151.4 ± 5.1^#	151 ± 4.7	150.6 ± 8.8	134.3 ± 13.1	121.8 ± 13.5
	MDA (nmol/mgprot)	8.3 ± 0.2	8.1 ± 0.1	7 ± 0.3	7.2 ± 0.3	7.1 ± 0.3	7.1 ± 0.3

, , and versus db/m⁺ mice, and versus vehicle-treated db/db mice.