Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis

Figure 4

The inflammatory response within the small intestinal muscularis propria in septic mice treated with PBS and septic mice treated with IL-17A-Ab. Samples were obtained 48 h after CLP. (a) Representative pictures of the small intestine stained with CD68 for macrophages. Quantification of the macrophages infiltrating the muscularis propria was compared. Scale bar: 100 μm. (b) The quantification of MPO, a marker of neutrophil activation, is presented among each group. (c) The activation of NF-κB and MAPK signaling was examined by DNA-binding activity. (d) The expression of IL-6, IL-1β, and NO was measured by ELISA. NF-κB: nuclear factor kappa B; MAPK: mitogen-activated protein kinase; MPO: myeloperoxidase (data are shown as the , to 7, ).

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