Targeting IL-17A Improves the Dysmotility of the Small Intestine and Alleviates the Injury of the Interstitial Cells of Cajal during Sepsis
The inflammatory response within the small intestinal muscularis propria in septic mice treated with PBS and septic mice treated with IL-17A-Ab. Samples were obtained 48 h after CLP. (a) Representative pictures of the small intestine stained with CD68 for macrophages. Quantification of the macrophages infiltrating the muscularis propria was compared. Scale bar: 100 μm. (b) The quantification of MPO, a marker of neutrophil activation, is presented among each group. (c) The activation of NF-κB and MAPK signaling was examined by DNA-binding activity. (d) The expression of IL-6, IL-1β, and NO was measured by ELISA. NF-κB: nuclear factor kappa B; MAPK: mitogen-activated protein kinase; MPO: myeloperoxidase (data are shown as the , to 7, ).
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.