Methylene Blue-Mediated Photodynamic Therapy Induces Macrophage Apoptosis via ROS and Reduces Bone Resorption in Periodontitis
MB-PDT prevents ligature-induced alveolar bone resorption and reduces inflammation in SD rats with periodontitis. (a) Results of micro-CT and HE. HE revealed bone loss in the furcation region and distal root of the maxillary first molar. Scale bars of micro-CT images, 1 mm. The average distance from the cementoenamel junction to the alveolar bone crest on the mesial surface of the maxillary first molar was calculated. Blue lines on HE images: horizon of the cementoenamel junction; yellow lines: alveolar bone crest. (b, c) TNF-α and IL-1β mRNA expression levels in the periodontium were measured by qPCR. (d, e) The levels of TNF-α and IL-1β in the periodontium were measured by ELISA. All results are expressed as the (). , , and . Abbreviations: B: buccal surface; P: palatal surface; M: mesial surface.