Triclosan: An Update on Biochemical and Molecular Mechanisms

Table 2

Summary of cell survival molecules modulated by TCS.

Model	Target		Response
	Gene/protein	Molecular identity
JEG-3 cells	Estradiol	Major female sex hormones	Upregulated by TCS
	Progesterone		Upregulated by TCS
	β-hCG	Maintenance of pregnancy	Downregulated by TCS
	Caspase-3	Apoptosis regulator; proapoptotic	Upregulated by TCS
BG-1 cells	Cyclin D1	Cell cycle regulators	Upregulated by TCS
	p21		Downregulated by TCS
	Bax	Apoptosis regulator; proapoptotic	Downregulated by TCS
MCF-7 cells	Cyclin D1	Cell cycle regulators	Upregulated by TCS
	Cyclin E		Upregulated by TCS
	p21		Downregulated by TCS
	Bax	Apoptosis regulator; proapoptotic	Downregulated by TCS
	Cathepsin B	Metastasis markers	Upregulated by TCS
	Cathepsin D		Upregulated by TCS
	MMP-9		Upregulated by TCS
	MMP-2		Upregulated by TCS
	CXCR4		Upregulated by TCS
	Snail	Mesenchymal markers	Upregulated by TCS
	Slug		Upregulated by TCS
LNCaP	p21	Cell cycle regulator	Downregulated by TCS
Primary human syncytiotrophoblasts	11β-HSD2	Fetal development; anticortisol	Downregulated by TCS
	Caspase-3	Apoptosis regulators; proapoptotic	Upregulated by TCS
	Bax		Upregulated by TCS
	Bcl-2	Apoptosis regulator; antiapoptotic	Downregulated by TCS
Rat neural stem cells	Caspase-3	Apoptosis regulators; proapoptotic	Upregulated by TCS
	Bax		Upregulated by TCS
	Bcl-2	Apoptosis regulator; antiapoptotic	Downregulated by TCS
Mouse neocortical neurons	GluN1	Ionotropic glutamate receptors; neurotransmission	Downregulated by TCS
	GluN1		Downregulated by TCS
	GluN2A		Downregulated by TCS
	GluN2A		Downregulated by TCS
	GluN2B		Upregulated by TCS
	GluN2B		Downregulated by TCS
	FasR	Apoptosis regulators; proapoptotic	Upregulated by TCS
	Caspase-8		Upregulated by TCS
	Caspase-9		Upregulated by TCS
	Caspase-3		Upregulated by TCS
	AhR	Ligand-activated receptor; detoxification	Upregulated by TCS
JB6 Cl 41-5a cells	Cyclin D1	Cell cycle regulators	Upregulated by TCS
	Cyclin A		Upregulated by TCS
	p27		Downregulated by TCS
B6C3F1 mice	Alp	Pluripotency markers; stem cell self-renewal and differentiation regulators	Downregulated by TCS
	Oct4		Downregulated by TCS
	Nanog		Downregulated by TCS
	ALP		Downregulated by TCS
	Oct 4		Downregulated by TCS
	Nanog		Downregulated by TCS
	Sox 2		Downregulated by TCS
	miRNA-134	Transcriptional regulator of pluripotency markers	Upregulated by TCS
D. rerio	Oct4	Pluripotency markers	Downregulated by TCS
	Nanog		Downregulated by TCS
	Sox2		Upregulated by TCS
	p53	Cell cycle regulator; tumor suppressor	Upregulated by TCS
	Casp3	Apoptosis regulators; proapoptotic	Upregulated by TCS
	Casp8		Upregulated by TCS
	Shha	Early neurogenesis	Sensitive to TCS sensitive to TCS
	Ngn1		Upregulated by TCS
	Nrd		Upregulated by TCS
	Elavl3		Upregulated by TCS
	α1-tubulin	Neural maturation	Upregulated by TCS
	Gap43		Upregulated by TCS
	Gfap		Downregulated by TCS
	Mbp		Downregulated by TCS

Abbreviation: Shha: sonic hedgehog a; Ngn1: neurogenin 1; Nrd: NeuroD; Elavl3: ELAV-like, neuron-specific RNA-binding protein 3; Gap43: growth-associated protein 43; Gfap: glial fibrillary acidic protein; Mbp: myelin basic protein.