Review Article
Triclosan: An Update on Biochemical and Molecular Mechanisms
Table 5
TCS genotoxicity and carcinogenicity.
| Model | Effect | Classification |
| HepG2 cells | Global DNA hypomethylation | Limited evidence of carcinogenicity | V79 cells | Chromosomal aberrations | Mouse | Somatic mutation (positive spot test) Increased incidence of liver tumors Aggravated hepatocellular carcinoma Exacerbated colon tumorigenesis |
| D. polymorpha | DNA damage (positive comet assay) | N/A | U. tumidus | DNA strand breaks (Hoescht 33342 fluorescence) | E. Fetida | DNA damage (positive Comet assay) | D. magna | DNA damage (positive Comet assay) | A. salina | DNA damage (positive Comet assay) | H. fossilis | DNA damage (positive Comet assay) | C. auratus | DNA damage (positive Comet assay) | O. mykiss | DNA damage (positive Comet assay) | T. thermophila | DNA damage (positive Comet assay) | A. cepa | Chromosomal stickiness, reduced mitotic activity, and ana-telophase bridges (positive Feulgen reaction) |
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N/A = data from non-mammalian animals are not considered for ECHA mutagenicity/carcinogenicity classification.
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