Study on the Multitarget Synergistic Effects of Kai-Xin-San against Alzheimer’s Disease Based on Systems Biology
The ameliorative effect of KXS on AD rat memory and learning impairment. KXS significantly shortened the escape latency and swimming distances (a) of rats bearing cognition impairment compared with those treated with a monotreatment of GR, PR, PO, and AT. KXS prolonged the time (b), swimming distance (c), and platform crossings (d) to find the removal platform in the target quadrant. Treatment with KXS resulted in the high expression of NeuN (e and f) and the activity of AChE (g) in the hippocampus. KXS did not cause loss of body weight, suggesting that KXS might probably not cause severe toxicity (h). The column diagrams marked by different letters were significant to each other at the 0.05 level according to Duncan’s multiple range test. Values were (),.