Study on the Multitarget Synergistic Effects of Kai-Xin-San against Alzheimer’s Disease Based on Systems Biology
In vitro therapeutic efficiency of KXS on Aβ25-35-induced PC12 cells. KXS significantly promoted the cell viability of PC12 compared with those treated with PR and/or PO and/or AT combined with the administering of the GR herb (a). Treatment with KXS resulted in the inhibition of inflammation revealed by an alleviation of TNF-α (b) and IL-1β (c). Detection of ROS reduction in PC12 cells treated with KXS (d). Morphological examination of Tubulin in PC12 cells treated with KXS and PR and/or PO and/or AT combined with the administering of the GR herb (e and f). The column diagrams marked by different letters were significant to each other at the 0.05 level according to Duncan’s multiple range test. Values were (),.