Oxidative Medicine and Cellular Longevity / 2019 / Article / Tab 1

Review Article

A Protective Role of the NRF2-Keap1 Pathway in Maintaining Intestinal Barrier Function

Table 1

The roles of Nrf2 in the protection of intestinal barrier in various disease models.

ModelThe effect of activating Nrf2Reference

S. typhimurium infectionOxidative stress and colitis decreased.Theiss et al. [11]
Dextran sodium sulfate-induced colitis modelNumbers of aberrant crypt foci decreased, and colonic proinflammatory cytokine, myeloperoxidase activity, 3-nitrotyrosine immunoreactivity, and lipid peroxidation decreased. Aconitase activity increased.Osburn et al. [12]
Burn-injured modelDamage of gut structure, intestinal permeability, and inflammatory cytokines (IL-6, IL-1β, MCP-1, intercellular adhesion molecule, and vascular cell adhesion molecule) decreased. NAD(P)H dehydrogenasequinine-1 and glutamate-cysteine ligase modifier subunit increased.Chen et al. [17]
Intestinal ischemia reperfusion injury modelMucosal 15-F2t-isoprostane was reduced. Endogenous antioxidant superoxide dismutase activity was elevated.Han et al. [14]
Rat liver transplantation modelHO-1 expression was elevated. Tight junction function was restored.Chi et al. [15]
Traumatic brain injury modelApoptosis-mediated intestinal epithelial cell damage was diminished. Intestinal permeability was improved.Liu et al. [19]
Aspirin/NSAID-induced vascular damage modelNSAID-induced vascular permeability was reduced. Mucosal MPO activity increased. Anaerobic enterobacterial count decreased.Yanaka et al. [16]
Severe sepsis modelInjuries caused by oxidative stress and inflammation were alleviated. HMGB1 levels was reduced, but HO-1 levels increased.Yu et al. [18]

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