Pretreatment Serum Uric Acid as an Efficient Predictor of Prognosis in Men with Laryngeal Squamous Cell Cancer: A Retrospective Cohort Study

Table 4

Univariate Cox regression analysis for overall survival, disease-free survival, and cancer-specific survival in patients with LSCC.

	OS		DFS		CSS
	HR (95% CI)		HR (95% CI)		HR (95% CI)
UA
	1		1		1
	1.466 (1.104-1.947)	0.008	1.463 (1.101-1.943)	0.009	1.457 (1.084-1.959)	0.013
UA/Cr ratio
UA/Cr	1		1		1
UA/Cr	1.308 (0.984-1.737)	0.044	1.350 (1.011-1.802)	0.042	1.391 (1.028-1.881)	0.032
TNM stage
I-II ()	1		1		1
III-IV ()	2.714 (2.034-3.620)	<0.001	2.882 (2.160-3.845)	<0.001	3.106 (2.291-4.211)	<0.001
T stage
T1-2 ()	1		1		1
T3-4 ()	2.391 (1.799-3.176)	<0.001	2.532 (1.905-3.365)	<0.001	2.726 (2.025-3.671)	<0.001
N stage
N0 ()
N1 ()	1		1		1
N2-3 ()	3.254 (2.123-4.783)	<0.001	3.409 (2.319-5.012)	<0.001	3.434 (2.317-5.090)	<0.001
Tumour subsite
Glottic and subglottic ()	1		1		1
Supraglottic ()	2.246 (1.675-3.013)	<0.001	2.382 (1.776-3.196)	<0.001	2.128 (1.653-2.975)	<0.001
Operation therapy
Partial laryngectomy ()	1		1		1
Total laryngectomy ()	2.473 (1.880-3.253)	<0.001	2.621 (1.992-3.449)	<0.001	2.468 (1.876-3.247)	<0.001
Tumour size
≤2 cm ()	1		1		1
>2 cm ()	2.650 (1.994-3.523)	<0.001	2.633 (1.981-3.500)	<0.001	2.766 (2.081-3.678)	<0.001
Age
<60 ()	1		1		1
≥60 ()	1.678 (1.253-2.247)	0.001	1.598 (1.193-2.139)	0.002	1.569 (1.160-2.122)	0.003
BMI
<22.94 (413)	1		1		1
≥22.94 (401)	0.841 (0.628-1.127)	0.246	0.855 (0.638-1.144)	0.292	0.859 (0.638-1.157)	0.316
Hypertension
No ()	1		1		1
Yes ()	1.254 (0.926-1.698)	0.143	1.300 (0.960-1.760)	0.090	1.218 (0.887-1.672)	0.224
Smoking history
No ()	1		1		1
Yes ()	1.057 (0.773-1.446)	0.727	1.103 (0.806-1.509)	0.540	1.106 (0.795-1.538)	0.549
Drinking history
No ()	1		1		1
Yes ()	1.111 (0.833-1.483)	0.474	1.162 (0.871-1.551)	0.308	1.139 (0.844-1.537)	0.396

UA: uric acid; UA/Cr ratio: uric acid/creatinine ratio; BMI: body mass index.