Artemether Activation of AMPK/GSK3β(ser9)/Nrf2 Signaling Confers Neuroprotection towards β-Amyloid-Induced Neurotoxicity in 3xTg Alzheimer’s Mouse Model

Figure 8

Artemether decreased the level of malonaldehyde (MDA) and increased the level of superoxide dismutase (SOD) in the brain cortex of 3xTg-AD mice. Artemether was administered to mice by intraperitoneal injection, once a day, at low doses of 5 mg/kg and high doses of 20 mg/kg, for 4 weeks. The levels of malonaldehyde (MDA) (a) and superoxide dismutase (SOD) (b) were determined using an enzyme-linked immunosorbent assay in wild-type (WT) compared to 3xTg-AD mice treated with either a low (Arte low) or high (Arte high) dose of Artemether or untreated (3xTg). and were considered significantly different. Five mice per group were used for analysis.

(a)

(b)