Research Article
Verapamil Attenuated Prediabetic Neuropathy in High-Fat Diet-Fed Mice through Inhibiting TXNIP-Mediated Apoptosis and Inflammation
Figure 2
Effects of verapamil on glucose intolerance and serum lipid profiles of HF mice. (a) The curve of ipGTT was shown based on plasma glucose concentrations in the indicated time. At weeks 8, 16, and 34, mice were fasted and injected with glucose. The blood was collected at 0 min, 30 min, 60 min, and 120 min from the tail vein, and the blood glucose levels were measured. (b) The AUC of the plasma glucose response was then calculated according to ipGTT results. (c) The serum levels of TG, TC, HDL-C, and LDL-C were determined. In the end of a 34-week study, four groups of mice were fasted for 12 h, and the blood serums were collected and TG, TC, HDL-C, and LDL-C were measured. Each value represents mean ± SEM (). ; .
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