miR-181c-5p Exacerbates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Targeting PTPN4

<div>Hypoxia/reoxygenation (H/R) enhanced LDH release (a) and reduced cell viability (b) that was concomitant with significantly enhanced expression of miR-181c-5p but not miR-181c-3p (c) in H9C2 cardiomyocytes. In in vivo studies, myocardial I/R (induced by 30 minutes of left anterior descending artery occlusion and 2 hours of reperfusion in rats) induced significant increase in expression of miR-181c-5p but not in miR-181c-3p (d) and increased postischemic myocardial infarction (e). 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Oxidative Medicine and Cellular Longevity

fig1

Figure 1

Figure 1: miR-181c-5p Exacerbates Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Targeting PTPN4 