Exosomes Derived from TIMP2-Modified Human Umbilical Cord Mesenchymal Stem Cells Enhance the Repair Effect in Rat Model with Myocardial Infarction Possibly by the Akt/Sfrp2 Pathway
huc-exoTIMP2 ameliorated oxidative stress-induced cardiomyocyte apoptosis. (a) TUNEL+ nuclei in cardiac sections. Scale bar: 50 μm. (b) The levels of MDA, SOD, and GSH concentrations in the heart tissues of different groups. (c) Immunoblots showing the expression levels of Bcl2, Bax, and pro-caspase-9 in heart tissues of different groups; comparison of quantified protein levels. Blank: rats without surgery; MI+PBS: MI rats treated with PBS; NC: MI rats treated with huc-exoNC; TIMP2: MI rats treated with huc-exoTIMP2. ,, and .
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