Exosomes Derived from TIMP2-Modified Human Umbilical Cord Mesenchymal Stem Cells Enhance the Repair Effect in Rat Model with Myocardial Infarction Possibly by the Akt/Sfrp2 Pathway
huc-exoTIMP2 inhibited cardiac fibroblast proliferation and MMP2/MMP9 production. (a) Cardiac fibroblast proliferation rate measured at 0, 24, 36, and 48 hrs with the CCK8 assay. OD540: optical density at 540 nm. (b) Immunoblots and (c) immunofluorescence showing the expression levels of α-SMA in cardiac fibroblasts and comparison of quantified levels. (d, e) Expression levels of MMP2 and MMP9 mRNAs and proteins in the cardiac fibroblasts across different groups. Control: untreated; TGFβ: treated with TGFβ alone; NC: treated with huc-exoNC following TGFβ; TIMP2: treated with huc-exoTIMP2 following TGFβ. ,, and .
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