Research Article

CIAPIN1 Targeted NHE1 and ERK1/2 to Suppress NSCLC Cells’ Metastasis and Predicted Good Prognosis in NSCLC Patients Receiving Pulmonectomy

Table 3

Univariate analysis of the association between clinical characteristics and survival in patients with NSCLC ( is considered statistically significant).

VariablesUnivariate analysisMultivariate analysis
Chi-squareHR (95% CI)

OS
Age (<60 years vs. ≥60 years)0.1710.679
Gender (male vs. female)0.0900.765
Smoking status (never smoker vs. smoker)2.7600.097
Histological type (squamous cell carcinoma vs. adenocarcinoma)2.8190.093
TNM stage (I, II, and III)4.2360.0400.644 (0.198-2.100)0.465
Tumor size (≤3 cm vs. >3 cm)6.8740.0090.397 (0.164-0.961)0.040
Lymphatic invasion (negative vs. positive)11.7120.0010.247 (0.086-0.704)0.009
CIAPIN1 expression (low vs. high)7.4010.0073.120 (1.084-8.977)0.035
DFS
Age (<60 years vs. ≥60 years)0.0030.959
Gender (male vs. female)0.1060.745
Smoking status (never smoker vs. smoker)2.1130.146
Histological type (squamous cell carcinoma vs. adenocarcinoma)1.6680.197
TNM stage (I, II, and III)3.0890.079
Tumor size (≤3 cm vs. >3 cm)7.9610.0050.354 (0.145-0.865)0.023
Lymphatic invasion (negative vs. positive)8.6030.0030.309 (0.115-0.828)0.020
CIAPIN1 expression (low vs. high)4.6770.0312.120 (0.784-5.734)0.139