Antioxidant and Anti-Inflammatory Properties of Anthocyanins Extracted from Oryza sativa L. in Primary Dermal Fibroblasts

Figure 10

A schematic of the antioxidant and anti-inflammatory properties of anthocyanins (ANT) extracted from Oryza sativa L. in primary dermal fibroblasts. Black rice-derived ANT suppressed reactive oxygen species (ROS) signaling, which regulates phosphor-Akt/extracellular signal-regulated kinases (ERK) and NF-κB p50/p65 signaling in inflammation, and modulated collagen type I alpha 2 (COL1A2) upregulation. In addition, ANT suppressed hydrogen peroxide- (H₂O₂-) induced interleukin- (IL-) 6 production. The present study demonstrated that ANT may promote collagen synthesis in the skin and function as antioxidants and anti-inflammatory substances.