Oxidative Medicine and Cellular Longevity / 2019 / Article / Fig 4

Research Article

Berberine Ameliorates Doxorubicin-Induced Cardiotoxicity via a SIRT1/p66Shc-Mediated Pathway

Figure 4

DOX-induced mitochondrial dysfunction can be significantly attenuated by Ber. (a) Effect of Ber on the decrease in the mitochondrial membrane potential (MMP) induced by DOX in H9c2 cells: (A) confocal images of in H9c2 cells (magnification, ×40); (B) summary data of the relative changes in Rh-123 fluorescence. (b) Effect of Ber on mitochondrial Ca2+ ([Ca2+]m) overload in rhod-2-AM-loaded H9c2 cells: (A) confocal images of [Ca2+]m in H9c2 cells (magnification, ×40); (B) summary data of the relative changes in Rhod 2-AM fluorescence. The results are presented as the . The data are representative of three separate experiments, each with three technical replicates (). △△ vs. control group, ## vs. DOX group, and vs. Ber+DOX group.
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