Nitric Oxide Influences HSV-1-Induced Neuroinflammation

Table 2

Cytokine and chemokine expression in mixed glial primary cultures.

	TNF-alpha	IFN-alpha	CXCL9	CXCL10
sFasL				n.d.
HSV-1
				552 ± 59

Cytokine and chemokine expression changes in the mixed glial cultures at 24 h p.i. with HSV-1. Mixed glial cultures were subjected to treatment with the NO donor—SNP (100 μM)—or the inhibitor of iNOS—AMG (50 μM). mRNA levels of IFN-alpha, TNF-alpha, CXCL9, and CXCL10 are shown as expression relative to control on the basis of the method. mRNA levels were counted from three PCR reactions for each sample. and versus HSV-1-infected control and and versus uninfected control. n.d. means not detected.